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Search Results for " solid tumors "

20

Compounds

Cat No. Product Name Synonyms Targets
T6796 CB-5083 CB5083,CB 5083 p97
CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor ( IC50=11 nM).
T3124 Carbendazim Bavistin,Carbendazole,Mercarzole Antifungal
Carbendazim (Mercarzole) is a broad-spectrum benzimidazole antifungal with potential antimitotic and antineoplastic activities. Although the exact mechanism of action is unclear, carbendazim appears to binds to an unspec...
T9430 Venadaparib NOV140101,IDX-1197 PARP
Venadaparib (NOV140101) (IDX-1197) is a potent, selective and orally active PARP inhibitor with IC50s of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively. Venadaparib is insensitive to PARP-5. Venadaparib prevents the...
T7318 Elimusertib BAY-1895344 ATM/ATR
Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy in monotherapy and strong combination potential with the target...
T13044 Mevociclib SY-1365 CDK
Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.
T2325 Neratinib HKI-272 EGFR , HER
Neratinib (HKI-272) (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively.
T26978 CEP-40125 RXDX-107 DNA Alkylation
CEP-40125 (RXDX-107) is a DNA alkylating agent for the study of advanced solid tumors.
T2619 CH5132799 PI3K , mTOR
CH5132799 has been used in trials studying the treatment of Solid Tumors.
T1601 Lomustine CCNU,NSC 79037 Apoptosis , Others , DNA Alkylator/Crosslinker , DNA Alkylation , Autophagy
Lomustine (NSC-79037) is an alkylating agent of value against both hematologic malignancies and solid tumors.
T7708 DL-Buthionine-(S,R)-sulfoximine Butionine sulfoximine,NSC 381100,D,L-Buthionine-(S,R)-sulfoximine Others , Ferroptosis
DL-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine) is an inhibitor of γ-glutamylcysteine synthetase for the treatment of solid tumors.
T73425 CFT8634
CFT8634 is a degrader targeting BRD9. CFT8634 can be used for the research of synovial sarcoma and SMARCB1-deleted solid tumors.
T79157 Pimicotinib ABSK021,ABSK-021 c-Fms , Others
Pimicotinib (ABSK021) is a potent CSF1R inhibitor with antitumor activity and can be used to study advanced solid tumors.
T36395 Trotabresib CC-90010 Epigenetic Reader Domain
Trotabresib (CC-90010) is an orally active inhibitor of BET and can be used in studies about advanced solid tumors.
T9929 Ramucirumab VEGFR
Ramucirumab is a human VEGFR-2 antagonist for the treatment of solid tumors.
T68144 Spiroplatin Others
Spiroplatin (TNO-6) is a novel platinum-containing analogue with antitumor activity that is commonly used in the study of solid tumors.
T71137 Simmitecan hydrochloride Topoisomerase
Simmitecan hydrochloride is a camptothecin derivative, a topoisomerase I inhibitor with anticancer activity, which can be used to study is solid tumors.
T12433 PF-06952229 PF06952229 TGF-beta/Smad
PF-06952229 is a selective inhibitor of TGFβRI. PF-06952229 can be used in studies about the treatment of solid tumors, specifically metastatic breast cancer.
T40199 Tulmimetostat CPI-0209 Histone Methyltransferase
Tulmimetostat (CPI-0209) is an orally active EZH1/EZH2 inhibitor.Tulmimetostat has antitumor activity and is used in the study of ovarian cancer and advanced solid tumors.
T2113 PHA-793887 PHA 793887,PHA793887 Apoptosis , CDK
PHA-793887 has been used in trials studying the treatment of Advanced/Metastatic Solid Tumors.
T76706 Varlilumab CDX-1127 TNF
Varlilumab (CDX-1127) is a novel human IgG1 anti-CD27 monoclonal antibody. Varlilumab has antitumor activity and can be used to study advanced solid tumors.
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TargetMol